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损伤相关分子模式是机体细胞在受损、应激或坏死时释放的内源性信号分子,通过与模式识别受体结合,触发无菌性炎症反应。其主要来源于受损细胞的胞内成分及细胞外基质成分。与病原体相关分子模式不同,损伤相关分子模式的本质是机体自身物质,在正常生理状态下通常被隔离或处于惰性状态,仅在组织损伤、缺血、炎症等病理条件下异常暴露或释放。根据其分子性质和功能特点,损伤相关分子模式可被系统分类为蛋白质、核酸、脂质和聚糖等主要类型。理解损伤相关分子模式的来源及其基于分子类型的分类,对于阐明无菌性炎症、自身免疫性疾病、缺血再灌注损伤、肿瘤免疫等多种病理过程的启动机制至关重要,并为相关疾病的诊断和治疗提供新的靶点。
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基本信息:
DOI:10.13401/j.cnki.jsumc.2026.01.008
中图分类号:R363
引用信息:
[1]王一涵,伍子建.损伤相关分子模式研究进展:分子起源、功能解析与临床意义[J].汕头大学医学院学报,2026,39(01):44-47.DOI:10.13401/j.cnki.jsumc.2026.01.008.
基金信息:
国家自然科学基金(82371049)